Impacts of HIV Treatment Regimens on Archived Drug Resistance
Recruiting now
Conditions studied: HIV -1 Infection, Antiretroviral Therapy, Drug Resistance, Microbial
In brief
The study aims to determine the prevalence of drug resistance mutation (DRM) in virally suppressed HIV infection, and the impacts of regimen change and the presence of low level viremia. Adults living with HIV infection on antiretroviral therapy (ART) with full viral suppression would be recruited. Cases are patients planning for regimen switch, while controls are those with and without low level viraemia (LLV) not planned for switch. Blood samples would be collected before and after switch. Sequencing would be performed to identify DRM present in HIV-1 proviral DNA.
Key facts
- Study ID
- NCT07643948
- Run by
- Chinese University of Hong Kong
- People needed
- 420
- Starts
- 2025-10-01
- Expected to finish
- 2029-12-31
- Last updated by the study team
- 2026-06-12
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients living with HIV who are (a) aged 18 or above, (b) on antiretroviral therapy, (c) has viral load <20 copies/mL at 2 time points for ≥6 months, (d) planning regimen switch.
- Patients for inclusion in the control group meet the same criteria (a) but they are not planned for switch. Controls include patients with low level viremia (LLV) as defined as ≥2 consecutive viral load level between 21 and 200 copies/mL in the preceding 2 years.
You may not qualify if…
- Patients living with HIV who (a) are pregnant, (b) have virologic failure, (c) are suffering from concurrent opportunistic infections, (d) are prisoners , (e) are unable to give consent, and (f) have mental illnesses.
Where it is running
- S.H. Ho Research Centre for Infectious Diseases, The Chinese University of Hong Kong — Hong Kong, Hong Kong, China (enrolling)
Full record on ClinicalTrials.gov
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