Evaluating the Effectiveness of Mobithron Xtra in Patients With Primary Knee Osteoarthritis Over a 3-month Period

Starting soon

Conditions studied: Osteoarthritis (OA) of the Knee

In brief

Knee osteoarthritis is a common condition that causes knee pain, stiffness, reduced mobility, and difficulty performing daily activities. Many patients seek non-surgical treatment options to help manage their symptoms and improve their quality of life. This study aims to evaluate the effectiveness and safety of Mobithron® Xtra, an oral health supplement containing hyaluronic acid, undenatured type II collagen, and Boswellia serrata extract, in adults with primary knee osteoarthritis. Participants will take Mobithron® Xtra once daily for 3 months as part of their routine care. The study will observe changes in knee pain, stiffness, physical function, treatment satisfaction, and overall perception of improvement using validated patient-reported outcome measures, including the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Visual Analogue Scale (VAS), Treatment Satisfaction Questionnaire for Medication (TSQM), and Patient Global Impression of Change (PGIC). This is a prospective, multicentre observational study involving patients receiving treatment in participating general practitioner clinics throughout Malaysia. No experimental procedures will be performed, and participants will continue to receive standard clinical care. Safety will be monitored throughout the study by documenting any adverse events reported by participants. The findings from this study may provide valuable real-world evidence regarding the role of Mobithron® Xtra in improving symptoms and quality of life among patients with primary knee osteoarthritis.

Key facts

Study ID: NCT07643662
Run by: University of Malaya
People needed: 100
Starts: 2026-07-01
Expected to finish: 2027-12-01
Last updated by the study team: 2026-06-11

Who can join

Age: 40 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Adults ≥40 years with primary knee osteoarthritis (OA)
Radiographic diagnosis of primary knee OA (Grade 2 or 3 on Kellgren-Lawrence scale)
Stable physiotherapy regimen for ≥3 months (if applicable).
Baseline VAS score ≥ 5
No prior surgical intervention for the affected knee

You may not qualify if…

Secondary OA (such as post-traumatic and inflammatory arthritis)
Grade IV Primary OA
Patients on analgesia (e.g., paracetamol, NSAIDs)
Patients on Mobithron (P/Advance/Xtra) or glucosamine products
Recent intra-articular injections within 6 months
Recent/planned knee surgery within 3 months
Severe comorbidities or cognitive impairment

Where it is running

Faculty of Medicine — Kuala Lumpur, Kuala Lumpur, Malaysia

Full record on ClinicalTrials.gov

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