Volume Removal Intolerance During Net Ultrafiltration in Acute Kidney Injury Patients

Recruiting now

Conditions studied: Acute Kidney Injury, Fluid Overload, Fluid Overload in Dialysis Patients, Critical Illness, Renal Replacement Therapy for Acute Kidney Injury in ICU

In brief

Acute kidney injury (AKI) is common in critically ill patients and is frequently associated with fluid overload, which can worsen clinical outcomes. Continuous renal replacement therapy (CRRT) allows fluid removal through net ultrafiltration (UFNET), but some patients develop hemodynamic instability or signs of poor tissue perfusion during this process. The purpose of this prospective observational study is to evaluate tolerance to net ultrafiltration in critically ill patients with AKI receiving CRRT. The study will assess clinical, hemodynamic, ultrasound, perfusion, and biochemical parameters before and during fluid removal to identify factors associated with ultrafiltration intolerance. The investigators hypothesize that alterations in hemodynamic, perfusion, and congestion-related parameters can identify patients at increased risk of ultrafiltration intolerance before the development of overt hypotension. The results may help improve individualized fluid removal strategies and optimize the safety of CRRT in critically ill patients.

Key facts

Study ID

NCT07643597

Run by

Hospital Las Higueras

People needed

128

Starts

2026-07-06

Expected to finish

2027-12-01

Last updated by the study team

2026-07-08

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥18 years
• Admission to an Intensive Care Unit
• Acute kidney injury according to KDIGO criteria
• Prescription of continuous renal replacement therapy (CRRT) with net ultrafiltration
• Clinical stability considered sufficient to initiate net ultrafiltration according to the treating clinical team

You may not qualify if…

• Chronic kidney replacement therapy prior to ICU admission
• Pregnancy
• Limitation of therapeutic effort or goals-of-care decisions at admission or during the observation period
• Inability to perform hemodynamic or perfusion assessment
• Extracorporeal membrane oxygenation (ECMO)
• Refusal to participate in the study

Where it is running

• Hospital Universitario San José de Popayán — Popayán, Colombia (enrolling)
• Hospital General de Mexico — Mexico City, Mexico (enrolling)
• Hospital Las Higueras de Talcahuano — Talcahuano, Chile (enrolling)
• Hospital Clínico Dra. Eloísa Díaz Insunza de La Florida — Santiago, Chile
• Hospital General Enrique Garces — Quito, Ecuador
• Ospedale San Bortolo — Vicenza, Italy
• Hospital Cárdio Pulmonar — Salvador, Brazil
• Hospital Nacional Cayetano Heredia — Lima, Peru
• Hospital Clínico Regional de Concepción — Concepción, Chile
• Complejo Asistencial Dr. Victor Ríos Ruiz — Los Ángeles, Chile

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.