CleaRRAflow: Isotonic Solution vs. TPA for IVH Clearance

Enrolling by invitation · Phase 4

Conditions studied: Tissue Plasminogen Activator, Intraventricular Brain Hemorrhage

In brief

The study aims to investigate the effect of continuous tPA irrigation into the ventricles. Investigators believe it may be superior to the traditional every 8-hour bolus dosing and continuous isotonic solution irrigation alone. The protocol plans to analyze blood clearance and functional outcomes in the patients.

Key facts

Study ID

NCT07643493

Run by

David Dornbos

People needed

80

Starts

2026-07-31

Expected to finish

2029-05-31

Last updated by the study team

2026-08-06

Who can join

Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female, age 18 years and older
• Intraventricular hemorrhage requiring EVD placement for treatment as determined by the cerebrovascular neurosurgical faculty member caring for the patient as per standard of care
• Baseline mRS 0 or 1
• Consenting requirements met as outlined below

You may not qualify if…

• IVH of traumatic origin
• Inability to initiate treatment within 24 hours of presentation
• Incarcerated individuals, pregnant individuals, or other conditions as deemed by the investigator to potentially confound study data
• Presence of evidence of severe brainstem dysfunction on presentation (absence of brain stem reflexes, fixed/dilated pupils)

Where it is running

• UKHC — Lexington, Kentucky, United States

Full record on ClinicalTrials.gov

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