Impact of VNS With Rehab on Gait Post-Stroke

Recruiting now · Not applicable

Conditions studied: Upper Limb Deficit, Stroke Gait Rehabilitation, Stroke

In brief

This is a prospective, double-blinded, randomized controlled study to evaluate the impact of Vagus Nerve Stimulation (VNS) therapy on lower limb function.

Key facts

Study ID

NCT07643337

Run by

State University of New York at Buffalo

People needed

24

Starts

2026-06-01

Expected to finish

2028-02-23

Last updated by the study team

2026-06-11

Who can join

Age: 22 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Approved for Vagus Nerve Stimulation (VNS) and rehabilitation therapy
• ≥22 years and ≤ 80 years
• Only patients who elect to undergo VNS therapy for stroke-related upper limb deficits
• Residual active movement in the affected limb's thumb and other 2 fingers
• Stroke-related deficits in the lower limbs and gait with a Functional Ambulation Category (FAC) ≥3
• Able to follow simple instructions and independently walk short distances with or without external support or leg orthoses, but without manual contact with another person

You may not qualify if…

• Intact lower limb functions (Fugl-Meyer score=34)
• Not a candidate for VNS therapy according to FDA guidelines
• Pregnant patients

Where it is running

• University at Buffalo Neurosurgery — Buffalo, New York, United States (enrolling)

Full record on ClinicalTrials.gov

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