Cohort Study of Postoperative Cognitive Dysfunction After Off-Pump Coronary Artery Bypass Grafting

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Conditions studied: Postoperative Cognitive Dysfunction (POCD)

In brief

This prospective cohort study aims to investigate postoperative cognitive dysfunction in patients undergoing off-pump coronary artery bypass grafting. Eligible patients will be enrolled before surgery and followed after surgery. Cognitive function will be assessed using the Montreal Cognitive Assessment before surgery and at predefined postoperative time points. Perioperative clinical information, including preoperative assessment data, intraoperative monitoring parameters, and postoperative clinical data, will be collected. The study will evaluate the occurrence of postoperative cognitive dysfunction and explore its association with perioperative factors.

Key facts

Study ID

NCT07643194

Run by

Beijing Anzhen Hospital

People needed

600

Starts

2026-05-24

Expected to finish

2026-12-15

Last updated by the study team

2026-06-11

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18 years or older
• Scheduled to undergo elective off-pump coronary artery bypass grafting
• American Society of Anesthesiologists physical status classification I to IV
• Able to complete preoperative cognitive assessments, including the Mini-Mental State Examination and the Montreal Cognitive Assessment
• Written informed consent provided by the patient or family member

You may not qualify if…

• Emergency surgery
• Pre-existing diagnosed cognitive impairment or history of psychiatric disease
• Preoperative cognitive impairment
• Severe neurological disease, such as sequelae of stroke, that may interfere with cognitive assessment
• Severe visual or hearing impairment that prevents completion of cognitive assessment
• Inability to understand Chinese or presence of language communication barriers

Where it is running

• Beijing Anzhen Hospital, Capital Medical University — Beijing, Beijing Municipality, China

Full record on ClinicalTrials.gov

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