The Effect of Intravenous Dexketoprofen on the Severity and Incidence of Rebound Pain
Recruiting now · Not applicable
Conditions studied: Postoperative Pain, Pain Management, Rebound Pain, Interscalene Block
In brief
Orthopedic shoulder surgeries are associated with severe postoperative pain, particularly within the first 24-48 hours after surgery. In postoperative pain management, single or continue interscalene brachial plexus blocks, acetaminophen, nonsteroidal anti-inflammatory drugs (NSAIDs), and opioids administered as needed are commonly used as components of multimodal analgesia. Rebound pain is defined as severe postoperative pain (VAS ≥ 7) occurring within the first 24 hours after resolution of the block. It is considered an adverse effect of regional anesthesia and typically develops 8-12 hours after a single-shot nerve block. Risk factors for rebound pain include pre-existing pain, female sex, younger age, bone surgery, lack of intraoperative dexamethasone administration, and inadequate analgesia. The primary objective of this study is to evaluate the effect of intravenous dexketoprofen administered during the postoperative period on the incidence and severity of rebound pain in patients undergoing shoulder surgery with interscalene brachial plexus block
Key facts
- Study ID
- NCT07642674
- Run by
- Eskisehir Osmangazi University
- People needed
- 66
- Starts
- 2026-06-11
- Expected to finish
- 2027-01-01
- Last updated by the study team
- 2026-06-12
Who can join
Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age 18-70 years ASA score of I-III Arthroscopic shoulder surgery
You may not qualify if…
- Patients who do not wish to participate in the study Creatinine clearance <50 mL/ min Patients for whom NSAID use is contraindicated due to heart failure, Patients with psychiatric or cognitive dysfunction that would impair their ability to assess visual analog scale (VAS) pain scores Patients for whom peripheral nerve block is contraindicated
Where it is running
- Eskisehir Osmangazi Universıty Faculty of Medicine — Eskişehir, Odunpazarı, Turkey (Türkiye) (enrolling)
Full record on ClinicalTrials.gov
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