Prediction of Atrial Fibrillation Using Polygenic Risk Score

Recruiting now · Not applicable

Conditions studied: Atrial Fibrillation (AF)

In brief

The goal of this clinical trial is to learn whether a genetic risk score can help identify undiagnosed atrial fibrillation (AF) in adults who may have it. AF is an irregular heartbeat that raises the risk of stroke if not treated early. The main questions it aims to answer are: Can a polygenic risk score (PRS) - a score based on a person's genes - identify who is more likely to have AF? Does combining PRS with a person's medical history predict AF better than using medical history alone? Participants will: Wear a continuous ECG patch for 7 days to record heart rhythm Give a blood sample for genetic testing to calculate their PRS Use a six-lead handheld ECG device (HATIV® P30, VUNO Inc., Seoul, Republic of Korea) to check their own heart rhythm at home once or twice a week for 1 year Visit the clinic 5 times over 1 year Researchers will use the genetic and clinical information collected to build a scoring system that predicts who is at risk for AF.

Key facts

Study ID

NCT07641582

Run by

Seoul St. Mary's Hospital

People needed

800

Starts

2024-11-19

Expected to finish

2027-06-30

Last updated by the study team

2026-06-11

Who can join

Age: 20 and older, up to 79. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with symptoms suggestive of paroxysmal atrial fibrillation, such as intermittent palpitations or chest discomfort
• Asymptomatic patients aged 60 or older with at least one of the following risk factors for atrial fibrillation: hypertension, diabetes, coronary artery disease, valvular heart disease, cardiomyopathy, sleep apnea, hyperthyroidism, obesity (BMI greater than 30), or chronic alcohol dependence (drinking more than 3 times per week)

You may not qualify if…

• Age under 20 years or over 80 years
• Moderate or severe cognitive impairment
• Previously diagnosed with atrial fibrillation prior to study enrollment
• Does not consent to participate in the study

Where it is running

• The Catholic University of Korea Incheon St. Mary's Hospital — Incheon, South Korea (enrolling)
• The Catholic University of Korea Seoul St. Mary's Hospital — Seoul, South Korea (enrolling)
• The Catholic University of Korea Eunpyeong St. Mary's Hospital — Seoul, South Korea (enrolling)
• The Catholic University of Korea St. Vincent's Hospital — Suwon, South Korea (enrolling)
• The Catholic University of Korea Uijeongbu St. Mary's Hospital — Uijeongbu-si, South Korea (enrolling)

Full record on ClinicalTrials.gov

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