A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Osteoarthritis Pain

Starting soon · Phase 2 · Has a placebo group

Conditions studied: Osteoarthritis, Knee, Chronic Pain

In brief

The main purpose of this study is to test the safety and efficacy of study drug for the treatment of knee pain due to osteoarthritis (OA). This trial is part of the chronic pain master protocol H0P-MC-CPMP (NCT05986292), which is a protocol to accelerate the development of new treatments for chronic pain.

Key facts

Study ID: NCT07641517
Run by: Eli Lilly and Company
People needed: 150
Starts: 2026-07-01
Expected to finish: 2027-04-01
Last updated by the study team: 2026-07-20

Who can join

Age: 40 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Have presence of index knee pain for more than 12 weeks at screening
Have an x-ray supporting diagnosis of osteoarthritis according to the American College of Rheumatology with a Kellgren-Lawrence grade 2 to 4 radiographic classification of index knee
Have a body mass index ≤40 kilograms per meter squared (kg/m²) (inclusive)
Have stable glycemic control as indicated by a glycated hemoglobin (HbA1c) less than or equal to 10 at time of screening

You may not qualify if…

Are pregnant or breastfeeding
Have had a surgical procedure or therapeutic injection in the affected knee within 3 months prior to screening
Have presence of surgical hardware or other foreign body in the index knee
Have ongoing complex regional pain syndrome or other concurrent medical condition that could interfere with the evaluation of pain in the index knee.
Have had any joint replacement of the lower extremity, such as hip, knee or ankle, in the 6 months prior to screening
Have an abnormal blood pressure (BP) (systolic BP greater than 140 millimeters mercury (>140 mm Hg) and diastolic BP>90 mm Hg) at screening
Have history or current clinically significant cardiac disease, including arrhythmia, aortic aneurysm, heart failure, current electrolyte abnormalities, or any other conditions that could predispose to arrhythmia in the judgement of the investigator

Where it is running

Central Research Associates — Birmingham, Alabama, United States
Synexus Clinical Research US, Inc. — Phoenix, Arizona, United States
Arizona Research Center — Phoenix, Arizona, United States
Desert Oasis Healthcare Medical Group — Palm Springs, California, United States
Artemis Institute for Clinical Research — Riverside, California, United States
Artemis Institute for Clinical Research — San Diego, California, United States
CMR of Greater New Haven — Hamden, Connecticut, United States
Bradenton Research Center, Inc. — Bradenton, Florida, United States
Accel Research Sites - DeLand Clinical Research Unit — DeLand, Florida, United States
K2 MEDICAL Research THE VILLAGES — Lady Lake, Florida, United States
K2 Medical Research ORLANDO — Maitland, Florida, United States
Merritt Island Medical Research, LLC — Merritt Island, Florida, United States
Suncoast Research Group — Miami, Florida, United States
New Horizon Research Center — Miami, Florida, United States
Suncoast Clinical Research, Inc. — New Port Richey, Florida, United States
Renstar Medical Research — Ocala, Florida, United States
Precision Clinical Research — Sunrise, Florida, United States
Charter Research - Lady Lake — The Villages, Florida, United States
Conquest Research — Winter Park, Florida, United States
North Georgia Clinical Research — Woodstock, Georgia, United States
Northwestern University — Chicago, Illinois, United States
DelRicht Research — New Orleans, Louisiana, United States
Lucida Clinical Trials — New Bedford, Massachusetts, United States
MedVadis Research Corporation — Waltham, Massachusetts, United States
Great Lakes Research Group, Inc. — Bay City, Michigan, United States

Full record on ClinicalTrials.gov

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