Reperfusion Approach in Predicted In-hospital Delay for Primary PCI in STEMI

Starting soon · Phase 4

Conditions studied: STEMI - ST Elevation Myocardial Infarction

In brief

This study aims at evaluating of the effectiveness of in-hospital thrombolysis for ST-segment elevation myocardial infarction in PCI centers under conditions of predicted in-hospital delay (\>60 min after admission in PCI-center) of PCI. Following randomisation a strategy of early tenecteplase and additional antiplatelet and antithrombin therapy followed by catheterisation within 2-24 hours with timely coronary intervention as appropriate (or by rescue coronary intervention if required) in Group A will be compared to primary PCI performed according to local standards in Group B.

Key facts

Study ID

NCT07641231

Run by

National Medical Research Center for Cardiology, Ministry of Health of Russian Federation

People needed

240

Starts

2026-05-20

Expected to finish

2029-05-20

Last updated by the study team

2026-06-11

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age equal or greater than 18 years
• "Symptom onset-randomization" time interval <12 hours
• Predicted "diagnosis-pPCI" time interval equal or greater than 120 minutes
• Predicted "admission-pPCI" time interval equal or greater than 60 minutes
• Informed consent received

You may not qualify if…

• Medical history, procedures, medication administration or the presence of factors that would in general predispose to bleeding events and/or the inability to evaluate the study primary endpoint

Where it is running

• National Medical Research Center for Cardiology, Ministry of Health of Russian Federation — Moscow, Select A State, Russia

Full record on ClinicalTrials.gov

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