VR-Based Cognitive Stimulation Games for Delirium Prevention

Recruiting now · Not applicable

Conditions studied: Surgery, Delirium - Postoperative, Delirium

In brief

This trial aims to evaluate the feasibility, safety, and acceptability of a virtual reality (VR)-based cognitive stimulation game to reduce postoperative delirium among older surgical patients at high risk due to pre-existing cognitive impairment.

Key facts

Study ID

NCT07641153

Run by

The Methodist Hospital Research Institute

People needed

90

Starts

2026-04-24

Expected to finish

2029-05-01

Last updated by the study team

2026-06-11

Who can join

Age: any, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Men and women ≥65 years of age
• Have a pre-existing diagnosis of cognitive impairment (Montreal Cognitive Assessment Score of 15-24)
• Elective or emergency major surgery with the expectation of admission to the Intensive Care Unit following the surgery for three days following surgery

You may not qualify if…

• Pre-existing Intubation and invasive ventilation;
• history of severe mental illness;
• admission for a drug overdose;
• severe vertigo;
• history of severe postoperative nausea and vomiting;
• hearing and visual impairment;
• preexisting severe dementia (Montreal Cognitive Assessment Score < 15; and
• active delirium at the time of screening for eligibility criteria.
• Active suicidal ideation or behavior Screen failure after surgery
• Prolonged intubation after surgery (more than 24 hours)

Where it is running

• Houston Methodist Hospital — Houston, Texas, United States (enrolling)
• Houston Methodist Research Insititute — Houston, Texas, United States (enrolling)

Full record on ClinicalTrials.gov

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