Investigation of Pain Modulation Phenotypes in Female Patients With Fibromyalgia

Starting soon

Conditions studied: Fibromyalgia (FM), Quantitative Sensory Testing, Central Sensitization, PRESSURE PAIN THRESHOLD, Pain Perception

In brief

Fibromyalgia is characterized by altered pain processing, including impaired descending pain inhibition and central sensitization. While both mechanisms have been independently associated with disease severity, their interrelationship remains unclear. This cross-sectional study aims to investigate whether central sensitization symptoms mediate the relationship between conditioned pain modulation and fibromyalgia impact.

Key facts

Study ID

NCT07640607

Run by

Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey

People needed

82

Starts

2026-07-01

Expected to finish

2026-09-01

Last updated by the study team

2026-07-07

Who can join

Age: 18 and older, up to 65. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Having received a diagnosis of fibromyalgia according to the 2016 ACR diagnostic criteria
• Female patients aged 18-65
• Being literate
• Having signed the informed consent form upon agreeing to participate in the study

You may not qualify if…

• Being under 18 or over 65 years of age
• Having any condition that may lower the pain threshold or cause chronic pain (Rheumatoid Arthritis, Ankylosing Spondylitis, systemic inflammatory diseases, malignancies, etc.)
• Any neurological condition (stroke, traumatic brain injury, multiple sclerosis, Parkinson's disease, central nervous system malignancies…)
• Peripheral artery disease
• Severe cardiopulmonary insufficiency (stage 3-4)
• Uncontrolled systemic diseases such as hypertension and diabetes
• Presence of an active infection
• Pregnancy
• Presence of cognitive impairment, hearing loss, or communication difficulties that would prevent understanding of questionnaires and protocols

Full record on ClinicalTrials.gov

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