The Analgesic Efficacy of Dexmedetomidine Versus Fentanyl as an Adjuvant to Bupivacaine in Ultrasound Guided Peripheral Nerve Blocks as a Solo Anesthetic Technique in High Risk Patients Undergoing Unilateral Above Knee Amputation .

Recruiting now · Not applicable

Conditions studied: Analgesia Assessment, Above Knee Amputation, Fentanyl vs Dexmedetomidine

In brief

The aim of this study is to compare the analgesic efficacy and safety of dexmedetomidine versus fentanyl as adjuvants to bupivacaine in ultrasound-guided combined supra-inguinal fascia iliaca and proximal sciatic nerve blocks used as a solo anesthetic technique in high-risk patients undergoing unilateral above knee amputation.

Key facts

Study ID

NCT07640516

Run by

Kasr El Aini Hospital

People needed

64

Starts

2026-07-01

Expected to finish

2027-03-01

Last updated by the study team

2026-07-13

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• - Age ≥18 years
• Both sexes
• ASA III-IV
• Documented cardiac disease (e.g., EF < 40%, NYHA II or higher)
• Documented pulmonary disease (e.g., COPD with FEV1 < 60%)
• Scheduled for above-knee amputations

You may not qualify if…

• Neurological or intellectual disability
• Drug abuse
• Allergy to study drugs
• Pregnancy
• Contraindications to regional anesthesia (e.g., coagulopathy, local infection)
• Significant renal or hepatic impairment( plts <75000 or INR >1.5)
• Current anticoagulant therapy
• severe haemodynamically unstability at the time of block performance, defined as map > 65 mmhg but achieved by high-dose vasopressors (e.g., norepinephrine ≥ 0.1 mcg/kg/min) after fluid ressuscitation .

Where it is running

• KasrELainiH — Cairo, Egypt (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.