Aortic Dissection Detection Risk Score With D-dimer to Rule-Out Acute Aortic Syndrome
Starting soon
Conditions studied: Acute Aortic Syndrome
In brief
The goal of this study is to evaluate the safety of integrating the Aortic Dissection Detection Risk Score (ADD-RS) and D-dimer testing for ruling out acute aortic syndrome (AAS) in the emergency department (ED). The main question it aims to answer: Can the combination of the ADD-RS \<2, and D dimer \<500ng/mL rule-out AAS in ED patients without CTA? The researchers will recruit patients suspected with AAS in the ED, and the patients will receive a ADD-RS score, a D-dimer testing after signing a written consent.
Key facts
- Study ID
- NCT07640334
- Run by
- Chinese University of Hong Kong
- People needed
- 746
- Starts
- 2026-07-13
- Expected to finish
- 2028-12-31
- Last updated by the study team
- 2026-08-05
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adult patients aged ≥ 18 years; AND
- Presentation to the ED with any of the following symptoms: acute onset (<14 days) chest pain, abdominal pain, back pain, syncope, or signs of malperfusion (e.g. limb ischemia, neurological deficit); AND
- AAS is considered as a possible differential diagnosis by the treating physician. Enrolment in the study will be determined by the attending physician during initial medical consultation in the ED and prior to establishing a final diagnosis.
You may not qualify if…
- An alternative diagnosis to AAS established by the treating physician after the initial assessment; OR
- Trauma cases; OR
- Patients with a known diagnosis of AAS before the index ED visit (e.g. with a diagnostic imaging done before the ED visit or referral from other institutions for AAS); OR
- Clinical severity or other conditions not allowing complete evaluation/proper enrolment; OR
- Patient who refuse to participate.
Where it is running
- Accident and Emergency Department, Queen Mary Hospital — Hong Kong, Hong Kong
- Prince of Wales Hospital — Shatin, Hong Kong
Full record on ClinicalTrials.gov
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