Randomized In-Vivo Comparison of 3D-Printed and Thermoformed Clear Aligners: A Multi-Subject, Time-Dependent Analysis of Adaptation and Trueness

Starting soon · Not applicable

Conditions studied: Adaptation of Different Types of Clear Aligners

In brief

This prospective clinical study aims to evaluate and compare the in vivo adaptation and trueness of clear aligners fabricated using thermoforming and direct three-dimensional (3D) printing technologies.

Key facts

Study ID

NCT07639515

Run by

University of Florida

People needed

20

Starts

2026-11-30

Expected to finish

2028-04-06

Last updated by the study team

2026-06-12

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy adult volunteers aged 18 years or older.
• Good general and oral health.
• Dentition adequate to support passive upper clear aligner wear, as determined by the investigator.
• Willing and able to attend all study visits over the 4-6 month study period.
• Willing and able to comply with aligner wear and all study procedures.
• Able to provide written informed consent and HIPAA authorization.

You may not qualify if…

• Active dental or periodontal disease, or any oral condition that could interfere with study procedures.
• Need for active orthodontic treatment or other dental procedures during the study period.
• Poor oral hygiene or failure to follow study instructions at the screening visit.
• Medical or systemic conditions, or use of medications, that could compromise participation or study outcomes.
• Concurrent participation in another interventional research study.
• Pregnancy or planned pregnancy during the study period (if applicable).

Full record on ClinicalTrials.gov

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