Fragmentation Vs Dusting With FANS for Renal Stones Less Than 2cm: A Randomized Controlled Study
Starting soon · Not applicable
Conditions studied: Thulium Fiber Laser, Fans, Lithotripsy, Laser, Renal Stone
In brief
The use of FANS has changed the operative landscape of RIRS by allowing continuous active suction-assisted clearance of ablated stone material in real time. Use of fragmentation technique in FANS requires high-energy to reduce stone burden into small fragments, followed by active suction of residual fine material. Dusting with FANS, on the other hand, converts the entire stone volume into sub-millimetre particulate that is continuously suctioned away during lasing potentially offering a more streamlined workflow with potentially less energy usage, reduced mechanical stress on the ureteroscope working channel, and fewer scope withdrawals. The combination of TFL dusting with FANS-assisted real-time evacuation may produce stone-free outcomes equivalent or superior to fragmentation, while offering these additional operative efficiencies. Whether dusting using TFL with FANS is non-inferior or indeed superior to fragmentation using TFL with FANS in terms of stone-free rate at one month has not been evaluated in prospective randomised trial yet. This study aims to answer that specific question in patients with renal stone less than 2 cm.
Key facts
- Study ID
- NCT07639385
- Run by
- Bir Hospital
- People needed
- 86
- Starts
- 2026-08-01
- Expected to finish
- 2027-08-07
- Last updated by the study team
- 2026-06-30
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age ≥18 years
- Renal stone(s) confirmed on non-contrast CT KUB
- Total stone less than 2cm
- Stone amenable to flexible ureterorenoscopy (FURS)
- FANS advanced beyond Pelvi-Ureteric Junction (PUJ)
- Able and willing to provide written informed consent
- Able to comply with follow-up schedule
You may not qualify if…
- Active urinary tract infection (positive urine culture) at time of planned surgery
- Anatomical anomalies precluding safe FURS (e.g., infundibular stenosis, severe calyceal diverticulum inaccessible to flexible scope)
- Pregnancy or breastfeeding
- Prior ipsilateral renal surgery within 3 months of enrollment
- Concurrent ureteral stone(s) requiring simultaneous treatment
- Renal anomalies: horseshoe kidney, ectopic kidney
- Sheathless procedure
- Unable to comply with follow-up or provide consent
- Participation in another interventional trial within 30 days
Full record on ClinicalTrials.gov
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