A Research Study Comparing Different Ways of Increasing the Dose of NNC0662-0419 in Participants With Obesity

Recruiting now · Phase 2 · Has a placebo group

Conditions studied: Obesity

In brief

The purpose of the study is to find out if NNC0662-0419 is safe and effective for treating participants living with obesity.

Key facts

Study ID

NCT07639021

Run by

Novo Nordisk A/S

People needed

230

Starts

2026-06-09

Expected to finish

2027-07-12

Last updated by the study team

2026-07-10

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female (sex assigned at birth, inclusive of all gender identities).
• Age 18 years or above at the time of signing the informed consent.
• Body mass index (BMI) greater than or equal to (≥) 30.0 kilogram per square meter (kg/m\^2) at screening.
• Participant must have a desire and be committed to lose at least 25 percentage (%) of their body weight from randomisation.

You may not qualify if…

• Known or suspected hypersensitivity to study intervention(s) or related products.
• Treatment with any medication prescribed for the indication of obesity or weight management (e.g. glucagon-like-peptide-1 (GLP-1) receptor agonists (RA), dual GLP-1/gastric inhibitory peptide (GIP) RAs (or any other GLP-1 based treatment) or amylin analogues)) within 90 days before screening.
• Glycated haemoglobin (HbA1c) ≥ 6.5% (48 Millimoles per mole [mmol/mol]) as measured by the central laboratory at screening.
• History of type 1 or type 2 diabetes mellitus.

Where it is running

• Isis Clinical Res. Ctr P.S.C. — Guaynabo, Puerto Rico (enrolling)
• FDRC — Costa Mesa, California, United States (enrolling)
• Los Angeles Institute for Metabolic Research — Los Angeles, California, United States (enrolling)
• Encore Medical Research LLC — Hollywood, Florida, United States (enrolling)
• South Broward Research LLC — Miramar, Florida, United States (enrolling)
• West Orange Endocrinology — Ocoee, Florida, United States (enrolling)
• Cedar-Crosse Research Center — Chicago, Illinois, United States (enrolling)
• Great Lakes Clinical Trials — Chicago, Illinois, United States (enrolling)
• Chambliss Clinical Trials, LLC — Montgomery, Alabama, United States (enrolling)
• L-MARC Research Center — Louisville, Kentucky, United States (enrolling)
• Endo And Metab Cons — Rockville, Maryland, United States (enrolling)
• StudyMetrix Research LLC — City of Saint Peters, Missouri, United States (enrolling)
• Great Lakes Medical Research — Westfield, New York, United States (enrolling)
• KDCILM, LLC & Accellacare US, Inc. — Wilmington, North Carolina, United States (enrolling)
• Family Practice Center of Wadsworth Inc. — Wadsworth, Ohio, United States (enrolling)
• UPA Ctr Weight and Eating Dis — Philadelphia, Pennsylvania, United States (enrolling)
• Clinical Res Collaborative — Cumberland, Rhode Island, United States (enrolling)
• Holston Medical Group_Bristol — Bristol, Tennessee, United States (enrolling)
• Holston Medical Group — Kingsport, Tennessee, United States (enrolling)
• Clinical Research Associates — Nashville, Tennessee, United States (enrolling)
• PlanIt Research, PLLC — Houston, Texas, United States (enrolling)
• Pinnacle Clinical Research — San Antonio, Texas, United States (enrolling)
• National Clin Res Inc. — Richmond, Virginia, United States (enrolling)
• Rainier Clin Res Ctr Inc — Renton, Washington, United States (enrolling)
• Midwest Inst For Clin Res — Indianapolis, Indiana, United States

Full record on ClinicalTrials.gov

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