Epidemiology of Invasive Bacterial Infections in Children With Sickle Cell Disease in France Between 2020 and 2025
Starting soon
Conditions studied: Sickle Cell Disease (SCD), Invasive Bacterial Infections
In brief
Children with sickle cell disease are at high risk of invasive bacterial infections, which may lead to serious complications. Preventive measures, including antibiotic prophylaxis and vaccination, have changed the epidemiology of these infections over time. New pneumococcal conjugate vaccines have recently become available, and updated data are needed to better understand which bacteria are currently responsible for invasive infections in this population. The aim of this retrospective study is to describe the bacterial distribution of invasive bacterial infections in children with sickle cell disease in France between 2020 and 2025. The results may help improve knowledge of these infections and guide future prevention strategies, including antibiotic management and vaccination policies.
Key facts
- Study ID
- NCT07639008
- Run by
- Assistance Publique - Hôpitaux de Paris
- People needed
- 350
- Starts
- 2026-07-15
- Expected to finish
- 2027-07-15
- Last updated by the study team
- 2026-06-10
Who can join
Age: any, up to 17. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Children with sickle cell disease aged under 18 years
- Hospitalized between January 2020 and December 2025
- Hospitalized for an invasive bacterial infection clinically defined as meningitis, pleuropneumonia, osteoarticular infection, or primary bacteremia
- Bacterium identified by culture or PCR
You may not qualify if…
- Opposition from the child or his/her parents
- Bacterium identified by serology
- Urinary tract infection
Where it is running
- Hôpital Victor Dupouy (CH Argenteuil) — Argenteuil, France
- CHI Robert Ballanger — Aulnay-sous-Bois, France
- Hôpital Jean Verdier — Bondy, France
- Hôpital Pellegrin - Hôpital des Enfants — Bordeaux, France
- Hôpital Ambroise Paré — Boulogne-Billancourt, France
- Hôpital Saint Camille — Bry-sur-Marne, France
- Hôpital NOVO — Cergy-Pontoise, France
- Hôpital Antoine Béclère — Clamart, France
- CH Sud Francilien — Corbeil-Essonnes, France
- CHI Créteil — Créteil, France
- CH du Sud Seine et Marne — Fontainebleau, France
- CH Gonesse — Gonesse, France
- GHEF, Site de Marne-la-Vallée — Jossigny, France
- Hôpital Bicêtre — Le Kremlin-Bicêtre, France
- GHT Yvelines Nord — Mantes-la-Jolie, France
- Hôpital Nord, AP-HM — Marseille, France
- GHEF, Site de Meaux — Meaux, France
- GH Sud Ile-de-france — Melun, France
- GHI Le Raincy-Montfermeil — Montfermeil, France
- CHU Nantes — Nantes, France
- CH Rives de Seine, Site de Neuilly-sur-Seine — Neuilly-sur-Seine, France
- CHU Lenval — Nice, France
- Hôpital Paris-Saclay — Orsay, France
- Hôpital Necker — Paris, France
- Hôpital Robert Debré — Paris, France
Full record on ClinicalTrials.gov
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