Effect of Individualized Positive End-expiratory Pressure (PEEP) in Patients Who Have an Intrinsic PEEP During One-lung Ventilation
Starting soon · Not applicable
Conditions studied: Pulmonary Disease (COPD), Chronic Obstructive, Lung Resection Surgery
In brief
This study investigates the effects of three extrinsic PEEP settings-5 cmH2O, 0 cmH2O, and an individualized PEEP (70% of the measured intrinsic PEEP)-on intrinsic PEEP and hemodynamic stability in patients with intrinsic PEEP undergoing lung resection surgery, using a randomized, crossover design.
Key facts
- Study ID
- NCT07638176
- Run by
- Samsung Medical Center
- People needed
- 48
- Starts
- 2026-06-01
- Expected to finish
- 2027-05-31
- Last updated by the study team
- 2026-06-10
Who can join
Age: 19 and older, up to 100. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- American Society of Anesthesiologists Physical Status I - III
- The Eastern Cooperative Oncology Group Performance Status Grade 0 - 2
- Lung resection surgery requiring one-lung ventilation for over 60 minutes
- Indication of double-lumen endobronchial tube (female 35 Fr, male 37 Fr)
- Patient who is diagnosed with intrinsic PEEP during one-lung ventilation
You may not qualify if…
- Large bullae
- Emergency surgery
- Mechanical ventilation before surgery
- Hemodynamic instability before surgery
- Surgery requiring cardiopulmonary bypass
- Pregnancy, breastfeeding patient
- Patient's refusal to participate
- No intrinsic PEEP during one-lung ventilation
Full record on ClinicalTrials.gov
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