Characterizing the Effects of Platelet-Rich Fibrin (PRF) as a Palatal Wound Dressing on Quality of Life and Sleep Following Mucogingival Surgery. Study Was Conducted at the Air Force Post Graduate Dental School. All HIPPA Consents and Research Informed Consents Are Located at JBSA-Lackland.

Completed · Not applicable

Conditions studied: Palatal Donor Site Wound Healing, Platelet Rich Fibrin, Sleep Quality, Pain, Analgesic Consumption

In brief

The goal of this clinical trial (2-arm) is to determine if the application of platelet rich fibrin (PRF) to palatal donor sites influence patients quality of life, sleep efficiency, and healing following mucogingival surgery. All patients were enrolled in the Air Force Post Graduate Dental School periodontics program and each patient required mucogingival surgery. The main question\[s\] it aims to answer \[is/are\]: * Does the application of PRF to palatal donor sites influence patient's quality of life following mucogingival surgery. \[outcome measure 1\] * Does the application of PRF to palatal donor sites influence patient's sleep quality following mucogingival surgery. \[outcome measure 2\] * Does the application of PRF to palatal donor sites influence palatal healing following mucogingival surgery. \[outcome measure 3\] Researchers will compare the application of PRF (test) as a palatal dressing to a commercially available product (control; oxidized cellulose membrane or collagen dressing) to determine the difference of effects. Participants will be randomly assigned to either receiving PRF or a commercially available product on the day of surgery. A survey response will be conducted at five time points (pre-operative, 24-hours, 72 hours, 1 week, 2 week) to obtain a quality of life metric. Sleep data was collected via a wearable device one week pre-surgical intervention and two weeks postoperatively. Finally, a clinical healing index was performed at 1 and 2 weeks post-operatively to obtain a healing score.

Key facts

Study ID

NCT07637838

Run by

59th Medical Wing

People needed

78

Starts

2024-05-24

Expected to finish

2025-03-18

Last updated by the study team

2026-06-10

Who can join

Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• age > 18 or < 99
• required a mucogingival surgery
• had not taken an antibiotic for one month
• planned for a non-emergent periodontal procedure

You may not qualify if…

• pregnant or within 6 months post-partum
• female subjects who are nursing
• subjects who are decisionally challenged
• patients who have undergone antibiotic therapy in the past month
• ASA IV or higher status
• patients who have undergone chronic therapy with medications that could affect periodontal status or healing
• incompatible mobile phone devices.

Where it is running

• Air Force Post Graduate Dental School — San Antonio, Texas, United States

Full record on ClinicalTrials.gov

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