Dry Weight Reduction Intervention Via Extra Ultrafiltration

Starting soon · Not applicable

Conditions studied: Fluid Accumulation, Blood Pressure Management, End Stage Renal Disease (ESRD)

In brief

Most patients who receive hemodialysis treatments have excess fluid in their body that has slowly built up over the course of kidney disease. This extra fluid is the main cause of high blood pressure in dialysis and leads to stress on the heart and lungs.that causes debilitating symptoms and frequent hospitalizations. This trial will test whether a focused program of 4 or 8 weeks of extra ultrafiltration treatments can remove most of this extra fluid. We believe that getting rid of large amounts of extra fluid will result in sustained improvements in blood pressure and symptoms. Ultrafiltration is a gentler type of dialysis that removes fluid but does not clean the blood.

Key facts

Study ID

NCT07637110

Run by

University of Washington

People needed

120

Starts

2026-06-01

Expected to finish

2030-11-01

Last updated by the study team

2026-06-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Receiving thrice weekly in-center hemodialysis treatments for end stage kidney disease for at least four weeks and clinical suspicion of volume excess based on either:
• Persistent hypertension defined by three consecutive pre-dialysis systolic blood pressures ≥140 mmHg or three consecutive pre-dialysis systolic blood pressures 130-140 mmHg plus use of at least two anti-hypertensive medications that can be tapered.
• OR
• Symptoms of congestion defined by a 12-item Kidney Modified Kansas City Cardiomyopathy Questionnaire (KM-KCCQ) score <75.

You may not qualify if…

• Age <18 years
• Receiving hemodialysis treatments for acute kidney injury
• Receiving hemodialysis treatments for less than four weeks
• Planned switch to peritoneal or home dialysis within next three months
• Current or planned incremental hemodialysis (less than 3 treatments per week)
• Current or planned intensive hemodialysis (four or more treatments per week)
• Scheduled kidney transplantation
• Major cardiovascular or bleeding event within previous 90 days
• Receiving chemotherapy or radiation treatment for cancer
• History of cirrhosis with ascites
• Inability to complete 24-hour ambulatory blood pressure measurement
• Wheelchair dependance or other inability to complete six-minute walk test
• Pre-dialysis systolic blood pressure <100 mmHg
• Scheduled use of midodrine with hemodialysis treatments
• History of non-adherence with dialysis treatments
• Pregnancy
• Institutionalized
• Current or pending enrollment in hospice care
• Inappropriate for enrollment based on investigator or nephrologist discretion

Where it is running

• Northwest Kidney Centers — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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