Association Between Fatty Liver and Inflammatory Biomarkers
Starting soon
Conditions studied: Fatty Liver
In brief
The newly adapted definition for MASLD includes evidence for hepatic steatosis by imaging or biopsy with at least one of the five cardiometabolic criteria; BMI ≥ 25 kg/m2 (≥23 kg/m2 in Asian) or waist circumference \>94 cm in men, \>80 cm in women, fasting serum glucose ≥ 126 mg/dL or 2 hour post load glucose level ≥ 140 mg/dL or HbA1c ≥ 5.7% or on treatment for type 2 diabetes mellitus ,blood pressure ≥130/85 mmHg or antihypertensive treatment, plasma triglycerides ≥ 150 mg/dL or on lipid lowering drug, and plasma HDL cholesterol \< 40 mg/dL for men and \< 50 mg/dL for women or on lipid lowering drug treatment (Rinella et al., 2024). These metabolic factors contribute to disease progression from simple steatosis to metabolic dysfunction-associated steatohepatitis (MASH), advanced fibrosis, cirrhosis, and hepatocellular carcinoma (Eid et al., 2024). While multiple biological pathways contribute to MASLD pathogenesis; systemic inflammation has emerged as a pivotal mechanism linking metabolic dysfunction to liver injury (Bessone et al., 2019)
Key facts
- Study ID
- NCT07636915
- Run by
- Sohag University
- People needed
- 100
- Starts
- 2026-07-01
- Expected to finish
- 2027-03-01
- Last updated by the study team
- 2026-06-10
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patient older than 18 years were diagnosed with MASLD according to Delphi consensus criteria (Rinella et al., 2024). Attend to outpatient clinic of Tropical Medicine Department, Sohag University
You may not qualify if…
- Significant alcohol consumption (>20 g/day for females, >30 g/day for males).
- Other causes of chronic liver disease:
- Viral hepatitis (HBV, HCV)
- Autoimmune hepatitis.
- Wilson's disease.
- Hemochromatosis.
- Drug-induced liver injury.
- Active infection or acute inflammatory conditions.
- Malignancy.
- Pregnancy.
Where it is running
- Suhag university , faculty of medicine — Sohag, Egypt
Full record on ClinicalTrials.gov
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