Luspatercept vs Epoetin in Treating Poor Erythroid Engraftment for Hematological Malignancies
Starting soon · Phase 2/Phase 3
Conditions studied: Luspatercept, Epoetin, Poor Erythroid Engraftment, Hematological Malignancies
In brief
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective therapy for hematological malignancies. Nonetheless, poor graft function remains a life-threatening complication after allo-HSCT. Poor erythroid engraftment is associated with increased bleeding events and shorter survival. Current treatment methods such as epoetin or repeated red-cell transfusions are not effective for poor erythroid engraftment, with limited and transient responses. Retrospective studies suggested that luspatercept showed efficacy in patients with anemia post-transplantation or poor erythroid engraftment. However, there are no studies comparing luspatercept versus epoetin for the treatment of poor erythroid engraftment. Therefore, we conducted a randomized controlled study to compared the effect of luspatercept versus epoetin in treating poor erythroid engraftment for hematological malignancies.
Key facts
- Study ID
- NCT07636486
- Run by
- Nanfang Hospital, Southern Medical University
- People needed
- 90
- Starts
- 2026-06-15
- Expected to finish
- 2030-12-31
- Last updated by the study team
- 2026-06-09
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- 18-65 years
- Hematologic malignancies
- Poor erythroid engraftment after the first allo-HSCT
- Complete remission post-transplantation
- Eastern Cooperative Oncology Group performance status of 0-2
- Epoetin-naive
- Endogenous serum erythropoietin concentration <500 U/L
You may not qualify if…
- Life expectancy shorter than 30 days post-transplantation
- Any abnormality in a vital sign (e.g., heart rate, respiratory rate, or blood pressure)
- Patients with any conditions not suitable for the trial (investigators' decision)
Where it is running
- Department of Hematology, Nanfang Hospital, Southern Medical University — Guangzhou, Guangdong, China
Full record on ClinicalTrials.gov
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