The SAVOR Study: Appetite and Physiological Responses

Starting soon · Not applicable

Conditions studied: Anorexia of Aging, Malnutrition or Risk of Malnutrition

In brief

The study aims to identify key physiological factors that differentiate older adults with healthy appetites from those experiencing appetite decline. The investigators hypothesize that seniors experiencing appetite decline will exhibit distinct oro-sensory, gastrointestinal, and hormonal profiles compared to seniors with healthy appetites, suggesting underlying biological mechanisms contributing to reduced appetite.

Key facts

Study ID

NCT07636369

Run by

Singapore Institute of Food and Biotechnology Innovation

People needed

20

Starts

2026-06-01

Expected to finish

2026-10-01

Last updated by the study team

2026-06-09

Who can join

Age: 65 and older, up to 74. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Postmenopausal female
• Aged 65-74 years
• Habitual breakfast consumer (consumes breakfast between 7am to 10am)
• Willingness to consume meals and follow intervention protocol
• English speaking

You may not qualify if…

• BMI ≥ 27.5
• Diagnosed with medical condition that may influence appetite or microbiome (e.g. diabetes, thyroid disorders, gastrointestinal diseases)
• Currently taking any medications or supplements that may influence appetite or the microbiome (e.g. probiotics, antibiotics, appetite stimulants/suppressants) one month prior to their first visit in consultation with study physician, PI and study team
• Following a special diet for weight management (e.g. low-calorie, low carbohydrate)
• History of bariatrics surgery
• Intentional attempt to change body weight or composition
• History of severe vasovagal syncope (blackouts or near faints) following blood draw
• Drug abuse within last 5 years
• Excessive alcoholic beverage consumption > 2 servings per day (1 serving defined as 360 mL beer, 150 mL wine or 45 mL distilled spirits)
• Smoking (cigarette, e-cigarette, cigar, pipe, vape)
• Engaging in habitual vigorous physical activity (as defined by physical activity questionnaire-PAQ)
• Loose teeth or jaw pain
• Not missing > 2 non-wisdom molars
• Involvement in other clinical studies that may influence the outcome of the study
• A study team member or their immediate family member

Where it is running

• Clinical Nutrition Research Centre — Singapore, Singapore

Full record on ClinicalTrials.gov

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