Eccentric Muscle Training in Cardiac Rehabilitation

Recruiting now · Not applicable

Conditions studied: Strength Training Effects, HFrEF - Heart Failure With Reduced Ejection Fraction

In brief

The goal of this interventional study is to assess the training effects in a training schedule in which eccentric overload training and eccentric cycle training are used. Researchers will compare a training program of eccentric overload training and eccentric cycling training with a traditional training program of strength and cardio training in people with heart failure with reduced ejection fraction. This study will be delivered in a cardiac rehabilitation setting.

Key facts

Study ID

NCT07636343

Run by

University Hospital, Antwerp

People needed

3

Starts

2023-01-20

Expected to finish

2027-01-01

Last updated by the study team

2026-06-09

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• HFrEF patients with ejection fraction <40%
• Exercise intolerance (<85% of predicted VO2 peak)
• clinically stable for > 6 weeks, optimal medical treatment for > 6 weeks

You may not qualify if…

• Contra indications for cardiac exercise rehabilitation as per consensus guidelines and recommendations
• Musculoskeletal disorders that hamper (progression in) strength training
• Non-stabilized acute coronary syndrome
• Current acute heart failure (decompensation)
• Patient having sustained a recent (<3 months) procedure that could act as a confounder to increase VO2peak (i.e., coronary artery bypass graft surgery, percutaneous coronary intervention, cardiac resynchronization therapy, valve surgery or reparation)

Where it is running

• UHAntwerp — Edegem, Belgium (enrolling)

Full record on ClinicalTrials.gov

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