Effectiveness of Subgingival Instrumentation on Delaying End-stage Renal Disease Among Chronic Kidney Disease Patients
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Conditions studied: Chronic Kidney Disease, Periodontitis, End Stage Renal Disease (ESRD)
In brief
Chronic kidney disease (CKD) and periodontitis share a bidirectional inflammatory relationship, with cytokines such as IL-6, TNF-α, and hsCRP driving progression in both conditions. Non-surgical periodontal therapy (NSPT) has shown reductions in systemic inflammatory markers with emerging evidence of improved renal function, yet robust randomized controlled trials targeting pre-dialysis stage IV-V diabetic CKD patients remain lacking. In the Indian context, where diabetes-related CKD is rapidly rising and access to dialysis is limited, there is a clear lacuna in literature regarding the effectiveness of NSPT in delaying progression to end-stage renal disease. Hence, the present non-randomized clinical study is undertaken to address this gap.
Key facts
- Study ID
- NCT07635797
- Run by
- Postgraduate Institute of Dental Sciences Rohtak
- People needed
- 40
- Starts
- 2026-07-01
- Expected to finish
- 2027-12-01
- Last updated by the study team
- 2026-06-18
Who can join
Age: 40 and older, up to 70. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients aged 40-70 years.
- Type 2 diabetes mellitus with chronic kidney disease and currently on oral hypoglycaemic agents.
- Diagnosed with Stage IV or V (eGFR between 15-20 mL/min/1.73m²).
- Not undergoing dialysis.
- Presence of ≥20 natural teeth.
- Diagnosed with moderate (Stage II) (as per 2017 World Workshop classification) (Interdental CAL at site of greatest loss >2mm but <5 mm in ≥ 2 non-adjacent teeth).
- Willingness to provide written informed consent.
You may not qualify if…
- Patients already undergoing haemodialysis or renal transplantation.
- Patients on insulin therapy or taking SGLT2 inhibitors and GLP-1 receptor agonists.
- HbA1c level >8 %.
- Any Periodontal therapy within past 6 months.
- Immunocompromised patients.
- Any history of tobacco use.
- Pregnant or lactating women.
Where it is running
- Post Graduate Institute of Dental Sciences , Rohtak — Rohtak, Haryana, India
Full record on ClinicalTrials.gov
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