Study on the Diagnostic Cut-off Point of 24-hour Urinary Aldosterone Measured by Liquid Chromatography-Tandem Mass Spectrometry in the Diagnosis of Primary Aldosteronism in the Oral Sodium Loading Test
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Conditions studied: Primary Aldosteronism
In brief
Primary aldosteronism (PA) is the most common cause of secondary hypertension. Liquid chromatography - tandem mass spectrometry (LC-MS/MS) is more accurate than the traditional radioimmunoassay in measuring aldosterone. This study aims to establish a more precise diagnostic threshold for the oral sodium loading test (OSLT) by using LC-MS/MS to measure urinary aldosterone levels. We will combine the biochemical results of OSLT and other data from healthy volunteers and suspected PA patients to determine a new 24-hour urinary aldosterone threshold. We expect to improve the diagnostic accuracy of PA, helping clinicians identify this curable cause of hypertension earlier and more accurately, and achieving precise treatment.
Key facts
- Study ID
- NCT07635134
- Run by
- Peking Union Medical College Hospital
- People needed
- 800
- Starts
- 2025-04-01
- Expected to finish
- 2026-08-01
- Last updated by the study team
- 2026-06-09
Who can join
Age: 18 and older, up to 70. Sex: any. Healthy volunteers: accepted.
Where it is running
- Peking Union Medical Colledge Hospital — Beijing, Beijing Municipality, China (enrolling)
Full record on ClinicalTrials.gov
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