Personalized Nutritional Intervention in Patients Undergoing TIPS Insertion for Refractory Ascites to Prevent Overt Hepatic Encephalopathy

Starting soon · Not applicable

Conditions studied: Cirrhosis, Refractory Ascites, TIPS Insertion

In brief

This study will evaluate whether a nutritional intervention is better than another to reduce the incidence of overt hepatic encephalopathy in patients undergoing TIPS insertion for refractory ascites.

Key facts

Study ID

NCT07634237

Run by

McGill University Health Centre/Research Institute of the McGill University Health Centre

People needed

50

Starts

2026-06-15

Expected to finish

2029-12-15

Last updated by the study team

2026-06-08

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of cirrhosis
• TIPS planned for refractory ascites
• Being at least moderately malnourished

You may not qualify if…

• TIPS insertion for other reason than refractory ascites
• Budd Chiari Syndrome
• Complete or cavernomatous portal vein thrombosis
• Pre-TIPS recurrent or persistent overt hepatic encephalopathy
• Use of lactulose or rifaximin in the last 4 weeks
• Liver failure (MELD > 18 or Child Pugh score > 12)
• Heart failure (NYHA ≥ III or LVEF < 50%)
• Kidney failure (serum creatinine > 250µmol/L)
• Pregnancy or breastfeeding
• Previous Liver transplantation
• Unable to provide informed consent

Where it is running

• McGill University Health Centre — Montreal, Quebec, Canada

Full record on ClinicalTrials.gov

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