Exercise Interventions in Obstructive Sleep Apnea Syndrome

Starting soon · Not applicable

Conditions studied: Obstructive Sleep Apnea (OSA), Exercise Snacks, Physical Activity, Circadian Rhythm, Sleep

In brief

Obstructive Sleep Apnea Syndrome (OSA) is a condition characterized by repeated pauses or reductions in breathing during sleep, which can negatively affect sleep quality, daytime functioning, and physical capacity. Although regular exercise is known to have beneficial effects in OSA, the effects of different exercise approaches on circadian rhythm and functional capacity have not been sufficiently investigated.The primary aim of this study is to compare the effects of exercise snacking and aerobic exercise on circadian rhythm and functional capacity in individuals with OSA, in comparison with a control group. The secondary aim is to evaluate the effects of these exercise interventions on peripheral muscle strength, fatigue level, body composition, quality of life, and physical activity level.Participants will be randomly assigned to three groups: an aerobic exercise group, an exercise snacking group, and a control group. While the exercise groups will follow their respective intervention programs, the control group will continue their routine treatment.This study aims to answer whether exercise snacking, which consists of short bouts of exercise distributed throughout the day, may be an alternative or complementary approach to traditional aerobic exercise in individuals with OSA. In addition, this study aims to be the first randomized controlled trial evaluating the effects of exercise snacking on circadian rhythm and functional capacity in individuals with OSA.

Key facts

Study ID

NCT07634029

Run by

Istanbul University - Cerrahpasa

People needed

39

Starts

2026-09-01

Expected to finish

2028-02-01

Last updated by the study team

2026-06-08

Who can join

Age: 30 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Individuals diagnosed with OSAHS (AHI ≥ 15) confirmed by polysomnography, with moderate or severe disease, who have been receiving CPAP therapy for at least 3 months.
• Adults aged 30-65 years.
• No participation in any regular exercise program within the last 6 months.

You may not qualify if…

• Individuals with OSAHS and a body mass index (BMI) > 35 kg/m²
• Severe chronic pulmonary disease
• Neurological or musculoskeletal disorders that prevent exercise
• Unstable cardiovascular conditions
• Unstable metabolic conditions
• Severe psychiatric disorders such as bipolar disorder or schizophrenia
• Pregnancy or breastfeeding
• Individuals working night shifts or with schedules that may cause jet lag
• Use of steroid or hormone therapy
• Use of melatonin or sleep-regulating medications within the last 3 months
• Presence of acute infection or inflammation

Where it is running

• Istanbul University-Cerrahpaşa, Department of Physiotherapy and Rehabilitation, Istanbul, Türkiye — Istanbul, Turkey (Türkiye)

Full record on ClinicalTrials.gov

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