MenoZen VR for Menopause Symptom Management: Phase 2

Starting soon · Not applicable

Conditions studied: Menopause

In brief

The purpose of this research is to evaluate the feasibility, acceptability, tolerability, and clinical efficacy of MenoZen VR (virtual reality) for managing menopause symptoms in women.

Key facts

Study ID

NCT07633743

Run by

Mayo Clinic

People needed

40

Starts

2026-07-31

Expected to finish

2028-07-31

Last updated by the study team

2026-06-08

Who can join

Age: 45 and older, up to 60. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Women currently between 45-60 years of age;
• Have moderate to severe VMS, defined as 28 or more hot flashes per week (including night sweats) and were sufficient severity to prompt them to seek therapeutic intervention;
• Are English-speaking;
• Able to participate fully in all aspects of the study;
• Have understood and signed study informed consent;
• Have access to a computer or smartphone and home Wi-Fi;
• Willing to participate in weekly VR sessions for 8 weeks.

You may not qualify if…

• Women receiving systemic menopause hormonal therapy (progesterone, testosterone, estrogen). Low-dose topical vaginal estrogen is okay;
• Women receiving non-hormonal therapy for the management of hot flashes (fezolinetant or elinzanetant, any SSRI/SNRI, oxybytunin, and/or gabapentin being prescribed for hot flashes, if for other reasons and still with hot flashes then okay);
• Women receiving active cognitive behavioral therapy (CBT) for hot flashes. CBT for mood symptoms is okay;
• Have a known, active, untreated clinically significant psychiatric condition (severe depression, psychosis, bipolar disorder, or severe depression);
• Have severe visual, auditory, or vestibular impairments that may interfere with VR use;
• Have a facial/head deformity that will prohibit the wearing of a VR head mounted displace (HMD);
• Self-reported history of acute and/or severe motion sickness;
• Have had a seizure in the past year;
• Concurrently enrolled in another intervention trial for menopause symptoms;
• Have a known history of any condition or factor judged by the investigator to preclude participation in the study or which might hinder adherence.

Where it is running

• Mayo Clinic — Jacksonville, Florida, United States

Full record on ClinicalTrials.gov

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