Ondansetron Versus Lidocaine for Preventing Pain on Propofol Injection.

Starting soon · Not applicable · Has a placebo group

Conditions studied: Anesthesia Induction, Propofol Pain Injection

In brief

This is a prospective, single-center, randomized, double-blind controlled trial involving patients scheduled for elective surgery requiring general anesthesia with propofol induction. Participants are randomly assigned to one of three groups: the ondansetron group (8 mg IV), the lidocaine group (40 mg IV), or the control group (0.9% normal saline placebo). Study medications are administered intravenously over 5 minutes, ending 1 minute before anesthetic induction. the goal: To assess the efficacy of intravenous ondansetron versus lidocaine and placebo in reducing the incidence and intensity of pain associated with propofol injection in patients undergoing general anesthesia.

Key facts

Study ID

NCT07632144

Run by

Mongi Slim Hospital

People needed

156

Starts

2026-06-08

Expected to finish

2026-08-15

Last updated by the study team

2026-06-08

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• The study included patients who met all of the following criteria:
• Aged 18 years or older; Classified as ASA physical status I-III (Appendix 1); Provided written informed consent to participate in the study; Scheduled for elective surgery requiring general anesthesia with propofol induction.

You may not qualify if…

• Patients were not eligible for inclusion if they:
• Had received analgesics or antiemetics within 12 hours before surgery; Had communication difficulties or were unable to assess pain adequately (e.g., language barrier, dementia, impaired consciousness); Had a known allergy to ondansetron, lidocaine, or propofol; Did not receive propofol for anesthetic induction; Were pregnant or breastfeeding; Suffered from chronic pain or regularly used opioid medications; Did not have a 20-gauge intravenous catheter inserted on the dorsum of the hand; Declined participation in the study.
• Patients were excluded from the study if they experienced any complication during anesthetic induction, including:
• Anaphylactic shock or allergic reaction to study medications; Hemodynamic or respiratory instability.
• Patients who subsequently withdrew their consent were also excluded from the study.

Where it is running

• Mongi Slim Hospital — Tunis, Tunisia

Full record on ClinicalTrials.gov

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