Pseudoallergen-Free and Low-Histamine Diet in Adolescents With Chronic Spontaneous Urticaria
Enrolling by invitation · Not applicable
Conditions studied: Pediatric Chronic Spontaneous Urticaria
In brief
The goal of this clinical trial is to learn whether a histamine- and pseudoallergen-restricted diet can help reduce symptoms in people with chronic urticaria. It will also learn whether this diet changes the need for urticaria medication. The main questions it aims to answer are: Does the diet lower urticaria activity, including hives and itching? Does the diet improve disease control and quality of life? Does the diet change the need for urticaria medication? Which clinical or laboratory factors may affect response to the diet? There is no comparison group. Researchers will compare participants' symptoms before and after the diet. Participants will: Follow a structured histamine- and pseudoallergen-restricted diet Continue their usual urticaria treatment as recommended by their doctor Record or report their urticaria symptoms during follow-up Visit the clinic for assessment of symptoms, disease control, quality of life, medication use, and laboratory findings.
Key facts
- Study ID
- NCT07632040
- Run by
- Istanbul University
- People needed
- 120
- Starts
- 2025-11-24
- Expected to finish
- 2027-01-01
- Last updated by the study team
- 2026-06-08
Who can join
Age: 1 and older, up to 18. Sex: any. Healthy volunteers: not accepted.
You may not qualify if…
- Pure chronic inducible urticaria Urticaria secondary to an identified trigger IgE-mediated food allergy requiring a specific elimination diet Active infection or parasitic disease Oral corticosteroid use within the previous 4 weeks Current or recent biological treatment for chronic urticaria Coeliac disease Inflammatory bowel disease Known systemic mast cell disease Severe chronic systemic disease affecting diet, growth, or follow-up Significant malnutrition or a medical condition requiring a special diet Pregnancy or lactation in postmenarchal adolescents Inability or unwillingness of the child or family to adhere to the assigned dietary recommendation Incomplete follow-up data
Where it is running
- Istanbul University, Istanbul Faculty of Medicine, Department of Pediatric Allergy and Immunology — Istanbul, Fatih, Turkey (Türkiye)
Full record on ClinicalTrials.gov
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