Intermittent Low Oxygen Breathing: A First Study Testing Different Disease Stages in People Living With MS

Starting soon · Phase 1/Phase 2

Conditions studied: Multiple Sclerosis

In brief

This study will look at the safety, tolerability and feasibility of a non-invasive treatment called Acute Intermittent Hypoxia (AIH) in people with Multiple Sclerosis (MS) at different stages of the disease course.

Key facts

Study ID

NCT07631143

Run by

University of Saskatchewan

People needed

9

Starts

2026-07-01

Expected to finish

2028-08-01

Last updated by the study team

2026-06-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Group 1:
• People with a confirmed diagnosis of MS and advanced disability level (Expanded Disability Status Scale (EDSS) >6.5 and <9)
• Without relapse for at least 90 days prior
• Older than age 18
• Group 2:
• People with a confirmed diagnosis of relapsing remitting MS
• Acute disabling relapse onset within the past 4 weeks. A disabling relapse will be defined as at least 1.0-point increase on the EDSS.
• Older than age 18
• Group 3:
• People with a confirmed diagnosis of MS that is non-active and progressive (Primary or Secondary Progressive MS). Non-active will be defined as without MS relapse, new/enlarging or enhancing MRI lesions within the past 1 year.
• EDSS <=6.5
• Older than age 18

You may not qualify if…

• Pregnancy
• Any of the following documented respiratory disorders: obstructive sleep apnea, chronic obstructive pulmonary disease, uncontrolled asthma, hypoxic pulmonary disease, respiratory infection in the previous 3 months
• Ischemic cardiac disease
• Cardiac arrhythmia
• Severe hypertension (>160/100)
• Seizure disorders
• Medically unstable in another capacity
• Unable to provide informed consent

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.