Telerehabilitation Versus Face-to-Face LSVT BIG in Individuals With Parkinson Disease

Starting soon · Not applicable

Conditions studied: PARKINSON DISEASE (Disorder), Parkinson Disease (PD), Postural Balance, Parkinson Disease

In brief

This prospective, randomized controlled trial will enroll 40 individuals with idiopathic PD (Hoehn \& Yahr stages 1-3, MoCA ≥21). Participants will be randomly assigned in a 1:1 ratio to either a telerehabilitation LSVT BIG group or a face-to-face LSVT BIG group, with randomization stratified by Hoehn \& Yahr stage using a computer-based block randomization system. Both groups will receive the standard LSVT BIG® protocol consisting of 16 sessions over four weeks (4 days/week, 1 hour/session). Treatment content will include maximal daily exercises, functional component tasks, "big" gait training, and individually tailored hierarchy tasks. The telerehabilitation group will receive all sessions via synchronous video conferencing under physiotherapist supervision, while the face-to-face group will receive sessions in a clinical setting. Both groups will be assigned home exercise programs in accordance with the LSVT BIG® protocol, and treatment adherence will be monitored throughout the study. Outcomes will be assessed at baseline, after 4 weeks of treatment, and at 6-month follow-up. Primary outcomes include postural stability and fall risk assessed with the Biodex Balance System (anterior-posterior stability index, mediolateral stability index, general stability index, fall risk index, limits of stability) and motor and non-motor symptom severity assessed with the MDS-UPDRS (Parts I, II, and III). Secondary outcomes include dynamic balance (Mini-BESTest), functional mobility (Timed Up and Go Test, 10-Meter Walk Test), quality of life (PDQ-39), depression (Beck Depression Inventory), sleep quality (Parkinson's Disease Sleep Scale), fatigue (Parkinson Fatigue Scale), cognitive function (MoCA), and treatment satisfaction (Global Rating of Change Scale).

Key facts

Study ID: NCT07630792
Run by: Bezmialem Vakif University
People needed: 40
Starts: 2026-06-20
Expected to finish: 2028-06-30
Last updated by the study team: 2026-06-11

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Diagnosis of idiopathic Parkinson's disease
Hoehn and Yahr stage 1-3
Montreal Cognitive Assessment (MoCA) score ≥ 21
Ability to use a smartphone, tablet, or computer
Access to internet connection and basic digital literacy
Participation in activities outside the home at least 3 days per week

You may not qualify if…

Diagnosis of a neurological condition other than idiopathic Parkinson's disease
Change in antiparkinsonian medication regimen during the study period
History of deep brain stimulation
Visual or hearing impairment that would prevent participation in treatment or assessments
Severe cardiovascular, orthopedic, pulmonary, or systemic comorbidity contraindicating exercise
Diagnosis of severe depression, psychotic disorder, or uncontrolled psychiatric illness
Participation in another structured physiotherapy or rehabilitation program for
Parkinson's disease within the last three months

Full record on ClinicalTrials.gov

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