EARLY DIAGNOSIS OF SEPTIC DIC
Starting soon
Conditions studied: Disseminated Intravascular Coagulation (DIC), Reanimation, Septic Shock
In brief
Disseminated Intravascular Coagulation is a severe complication of septic shock, associated with high mortality, whose diagnosis relies on complex scores that are rarely used in practice. Preliminary studies have shown that increased neutrophil fluorescence is associated with Disseminated Intravascular Coagulation and could reflect NETosis, a key mechanism of immunothrombosis. This study aims to validate neutrophil fluorescence measured on the SthemA 801 analyzer, alone or integrated into an artificial intelligence model, as an early, reliable, and routinely usable biomarker for the diagnosis of septic Disseminated Intravascular Coagulation.
Key facts
- Study ID
- NCT07630415
- Run by
- University Hospital, Strasbourg, France
- People needed
- 492
- Starts
- 2026-06-15
- Expected to finish
- 2029-01-15
- Last updated by the study team
- 2026-06-05
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Male or female ≥ 18 years old
- Patient admitted to intensive care for septic shock
- Patient affiliated with a social security scheme or having rights
- No objection from the patient or a relative in case the patient is not able to express consent, or inclusion under emergency procedure in case the patient is not able to express their opinion and no relative of the patient is reachable.
You may not qualify if…
- Moribund patient on the day of inclusion
- Child-Pugh C cirrhosis
- Neutropenia (<500 mm3)
- Patient under legal protection
- Patient under guardianship or curatorship
- Pregnancy/ Breastfeeding
Where it is running
- The University Hospitals of Strasbourg, Intensive Care Medicine Department - New Civil Hospital — Strasbourg, France
Full record on ClinicalTrials.gov
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