The Effect of Standard vs. Shorter Filter Lifespan During Continuous Renal Replacement Therapy

Starting soon · Not applicable

Conditions studied: Acute Kidney Injury

In brief

This study aims to investigate shorter vs. standard filter lifespans in critically ill patients receiving continuous renal replacement therapy (CRRT) for acute kidney injury (AKI). The aim of this trial is to reliably implement,scheduled filter changes and to investigate whether shorter filter lifetime is associated with a lower incidence in rate of new infections.

Key facts

Study ID

NCT07630220

Run by

Universität Münster

People needed

100

Starts

2026-06-01

Expected to finish

2028-06-01

Last updated by the study team

2026-06-15

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult ≥ 18 years
• Critically ill patients with severe AKI consistent with KDIGO stage 3 and an absolute indication for CRRT
• Written consent form from the patient or legal representative or authorized representative or emergency inclusion

You may not qualify if…

• End-stage kidney disease or chronic dialysis dependence
• Chronic kidney disease with eGFR<20ml/min/1.73 m²
• Prior kidney transplant
• Prior renal replacement therapy during the index admission before randomization
• Glomerulonephritis, interstitial nephritis, vasculitis
• Patients on immunosuppression (above the cushing threshold)
• Patients with chronic inflammatory diseases (e.g. arthritis, HIV with a CD4 count of < 0.05 x 10E/l)
• Do-not resuscitate order
• Persons with any kind of dependency on the investigator or employed by the sponsor
• Patients participating in an interventional study involving measures to influence the immune system

Where it is running

• University Hospital Münster — Münster, Germany

Full record on ClinicalTrials.gov

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