Dementia With Lewy Bodies: Clinical Symptoms, Biomarkers and Progression

Recruiting now

Conditions studied: Dementia With Lewy Bodies (DLB), Mild Cognitive Impairment (MCI), Cognitively Unimpaired, Other Dementias

In brief

The goal of this observational study is to improve the detection of dementia with Lewy bodies (DLB) and its prodromal phases, as well as advancing our current understanding of biological mechanisms and therapeutic options. The data is acquired at cognitive clinics in Stockholm (Sweden) and combined with national and international data to increase statistical power, representativeness and replication of results. Participants undergo collection of clinical assessments, neuroimaging and fluid biomarkers.

Key facts

Study ID

NCT07629349

Run by

Karolinska Institutet

People needed

600

Starts

2020-01-01

Expected to finish

2031-03-01

Last updated by the study team

2026-06-05

Who can join

Age: any. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• At least one core clinical feature of dementia with Lewy bodies such as visual hallucinations, parkinsonism, cognitive fluctuations, or probable REM sleep behaviour disorder.

You may not qualify if…

• Causes of cognitive impairment other than those related to dementia or MCI. Current or pass drug use.

Where it is running

• Karolinska University Hospital — Stockholm, Sweden (enrolling)

Full record on ClinicalTrials.gov

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