Smart Discharges for Older Children

Recruiting now

Conditions studied: Sepsis

In brief

This study is an observational multi-country cohort study that aims to build algorithms that can identify children between 5 and 16 years of age admitted for proven or suspected sepsis who are at risk of mortality after they are discharged in East Africa. In low- and middle-income countries, about 5% of children discharged after hospitalization for sepsis will die in the weeks after returning home. Doctors and parents are often unaware of this period of vulnerability and are poorly equipped to identify or handle this critical situation. This project builds on past work that developed and evaluated models and the Smart Discharges program to predict, during hospitalization, an individual child's risk of recurrent illness and mortality, as well as to provide additional post-discharge support to at-risk children. Participants will be enrolled from facilities once they are admitted, collecting clinical and social variables. They will then be followed until 6 months post-discharge to understand what happens to them after they return home. This data will be evaluated to identify which variables collected at facilities can be predictive of mortality and recurrent illness after discharge.

Key facts

Study ID

NCT07629154

Run by

University of British Columbia

People needed

4000

Starts

2024-01-02

Expected to finish

2027-04-01

Last updated by the study team

2026-06-15

Who can join

Age: 5 and older, up to 16. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age between 0 and 16 years admitted to pediatric ward of hospital for proven or suspected infection
• Provide informed consent
• Ability to provide contact information (phone number or address) for phone or in-person follow-up

You may not qualify if…

• Child lives outside of the catchment area of a study site
• Admitted for elective procedures, trauma, or short-term observation
• Language barriers

Where it is running

• Catholic University Of Health And Allied Sciences — Mwanza, Tanzania (enrolling)
• The Rwanda Paediatric Association — Kigali, Rwanda (enrolling)
• University of Washington — Seattle, Washington, United States
• University of California, San Francisco — San Francisco, California, United States
• WALIMU — Mbarara, Uganda
• BC Children's Hospital Research Institute — Vancouver, British Columbia, Canada
• Weill Cornell Medicine — Ithaca, New York, United States

Full record on ClinicalTrials.gov

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