Prenatal Androgen and Skills

Enrolling by invitation

Conditions studied: Health Adults

In brief

Due to the difficulties and risks of directly measuring prenatal hormone levels, biomarkers that indirectly reflect this exposure are used in research. In this context, the ratio of second to fourth finger length (2D:4D) is widely preferred because it is an easily applicable and non-invasive measurement. Evidence shows that 2D:4D stabilizes from the second trimester of pregnancy onward and exhibits strong sex differences across populations. The 2D:4D ratio is generally lower in men than in women. 2D is more strongly influenced by prenatal estrogen, while 4D is more strongly influenced by prenatal testosterone; this occurs during the first trimester of intrauterine fetal development. To our knowledge, studies examining the relationship between the 2D:4D ratio, an indirect indicator of prenatal androgen exposure, and dexterity and tactile discrimination are limited. Accordingly, the planned study aims to evaluate the relationship between the 2D:4D ratio and fine motor skills and tactile discrimination in healthy young adults.

Key facts

Study ID

NCT07627113

Run by

Nigde Omer Halisdemir University

People needed

94

Starts

2026-07-01

Expected to finish

2027-07-01

Last updated by the study team

2026-06-04

Who can join

Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy individuals aged 18-40
• Having sufficient visual and auditory function to understand and administer the test,
• Voluntary agreement to participate in the study and providing informed consent.

You may not qualify if…

• Individuals with any musculoskeletal pathology,
• History of upper extremity trauma,
• Individuals diagnosed with metabolic, neurological, or genetic diseases,
• Individuals with a history of hand surgery within the last 6 months,
• Pregnancy or breastfeeding.

Where it is running

• Nigde Omer Halisdemir University — Niğde, Merkez, Turkey (Türkiye)

Full record on ClinicalTrials.gov

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