Hamstring Strengthening in Hypermobile Conditions

Starting soon · Not applicable

Conditions studied: Hypermobile EDS (hEDS), Hypermobile Ehlers-Danlos Syndrome, Hypermobile Spectrum Disorder, Hypermobility Type Ehlers-Danlos Syndrome

In brief

The goal of this clinical trial is to determine how strengthening the hamstring muscles affects the knee joint in people living with hypermobility spectrum disorders (HSD) and hypermobile Ehlers-Danlos syndrome (hEDS). The main questions it aims to answer are: * Does hamstring strengthening reduce the looseness of the knee joint in HSD/hEDS? * Does hamstring strengthening improve clinical outcomes like pain in people living with HSD/hEDS? Participants will: * Attend two exercise classes per week for 12 weeks. * Visit the laboratory every 4-6 weeks for testing.

Key facts

Study ID

NCT07626957

Run by

University of Calgary

People needed

20

Starts

2026-06-01

Expected to finish

2027-08-01

Last updated by the study team

2026-06-04

Who can join

Age: 18 and older, up to 55. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Reported diagnosis of HSD or hEDS by a physician
• Meet the 2017 International Diagnostic Criteria for HSD and hEDS
• Clearance to participant in exercise participation, determined using the Get Active Questionnaire

You may not qualify if…

• Other acquired or hereditary connective tissue disorder (i.e., rheumatoid arthritis, Marfan syndrome, etc.)
• Currently experiencing daily knee pain
• Prior knee injury or surgery
• Intra-articular knee injection in the last 12 months
• Currently pregnant

Where it is running

• University of Calgary - Foothills Campus — Calgary, Alberta, Canada

Full record on ClinicalTrials.gov

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