Comparison of Rate of Tooth Movement Between MOPs vs MOPs & LLLT Combined

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Conditions studied: Orthodontic Tooth Movement, Low Level Laser Therapy, Canine Retraction

In brief

Orthodontic treatment is often prolonged, requiring years to achieve desirable outcomes. The prolonged duration of treatment increases the risk of complications such as root resorption, periodontal damage, and patient non-compliance. To address these concerns, various methods have been explored to accelerate orthodontic tooth movement, including pharmacological agents, mechanical vibration, corticotomies, and minimally invasive techniques like Micro-Osteoperforations (MOPs) and Low-Level Laser Therapy (LLLT). Micro-Osteoperforations (MOPs) have gained popularity as a minimally invasive technique that enhances bone remodeling by inducing a localized inflammatory response, thereby accelerating tooth movement. Studies have shown that MOPs can effectively stimulate the expression of cytokines, increasing osteoclastic activity and facilitating rapid orthodontic tooth movement. However, the extent of its effectiveness varies among individuals, necessitating additional interventions to maximize efficiency. Low-Level Laser Therapy (LLLT), also known as photobiomodulation, is another promising adjunct in orthodontics. LLLT has been reported to enhance cellular activity, promote osteoblastic and osteoclastic function, and improve tissue healing, leading to accelerated tooth movement. Several studies suggest that LLLT alone can expedite orthodontic treatment, but its combination with MOPs has not been extensively explored. This study aims to compare the rate of orthodontic tooth movement between MOPs alone and MOPs combined with LLLT. By evaluating these two techniques, this research seeks to determine whether LLLT enhances the effectiveness of MOPs in accelerating tooth movement. The findings of this study could provide valuable insights into optimizing orthodontic treatment duration while minimizing potential risks and discomfort for patients.

Key facts

Study ID

NCT07626580

Run by

Riphah International University

People needed

33

Starts

2026-06-01

Expected to finish

2026-12-01

Last updated by the study team

2026-06-04

Who can join

Age: 18 and older, up to 30. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• • Patients aged 12-30 years requiring fixed orthodontic treatment.
• Patients with Class I or mild-to-moderate Class II malocclusion requiring canine retraction.
• No history of previous orthodontic treatment.
• Patients with indications for the extraction of the first premolars on both sides of the maxilla.

You may not qualify if…

• • Patients with systemic conditions affecting bone metabolism (e.g., osteoporosis, diabetes).
• Smokers and individuals with poor oral hygiene.
• Pregnant or lactating women.

Where it is running

• Islamic International Dental Hospital — Islamabad, Punjab Province, Pakistan

Full record on ClinicalTrials.gov

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