HBO After Thrombectomy for AIS With LVO

Recruiting now · Not applicable

Conditions studied: Acute Ischemic Stroke From Large Vessel Occlusion

In brief

The purpose of this RCT trial is to evaluate whether the sequential hyperbaric oxygen therapy can improve the 90-day functional outcome in patients with acute large vessel occlusion ischemic stroke after endovascular treatment.

Key facts

Study ID

NCT07626450

Run by

Beijing Tiantan Hospital

People needed

420

Starts

2026-06-01

Expected to finish

2027-10-01

Last updated by the study team

2026-06-04

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18\~80 years;
• Clinically diagnosed as acute large vessel occlusive ischemic stroke, suitable for and received endovascular treatment according to current clinical guidelines;
• The onset of stroke or the last normal time to the time of endovascular treatment ≤ 24 hours;
• Pre-stroke mRS score of 0 or 1;
• Baseline NIHSS score before endovascular treatment ≥ 6 points in the anterior circulation or ≥10 points in the posterior circulation;
• CTA, MRA, or DSA angiography before endovascular treatment confirmed occlusion of large vessels (internal carotid artery, middle cerebral artery M1 segment, basilar artery), consistent with symptoms and signs;
• The corresponding anterior circulation ASPECTS score or posterior circulation pc-ASPECTS score ≥ 6 points;
• The pontine midbrain index (PMI) of patients with acute basilar artery occlusion ≤3;
• Patients or their family members sign the informed consent form.

You may not qualify if…

• Patients with extensive bleeding or severe increase in infarct area, midline displacement (>0.5cm), etc. during endovascular treatment, who plan to undergo bone valve decompression or ventricular drainage;
• Known bleeding risk factors, including coagulation factor deficiency, or receiving anticoagulant therapy, INR>3.0 or APTT > 3 times normal or platelet count less than 50×10⁹/L;
• Severe hepatic or renal dysfunction (severe hepatic dysfunction refers to ALT or AST > 3 times the upper limit of the normal range, severe renal dysfunction refers to serum creatinine Cr >1.5 times the upper limit of the normal range);
• Females of pregnancy, or positive pregnancy test prior to randomization;
• Severe persistent and medication-uncontrollable hypertension (systolic blood > 185 mmHg or diastolic blood > 110 mmHg)
• Baseline blood glucose of <50 mg/dL (2.78 mmol/L) or >400 mg/dL (22.20 mmol/L);
• The oxygen required to maintain 95% of peripheral arterial oxygen saturation (SaO2) under the current medium-term management guidelines > 3L/min;
• End-stage disease other than the nervous system, life expectancy < 90 days;
• Participating in other drug or medical device clinical trials;
• CT or MR suggests intracranial tumors (other than meningiomas) or other high-risk intracranial vascular malformations;
• Patients with anemia, polycythemia or other conditions requiring urgent oxygen;
• Unable to cooperate with hyperbaric oxygen therapy, or have other diseases that are not suitable for hyperbaric oxygen therapy (such as active/chronic obstructive pulmonary disease, acute respiratory distress syndrome, tension pneumothorax, tension pneumocephalus, etc.).

Where it is running

• Beijing Tiantan Hospital — Beijing, Beijing Municipality, China (enrolling)

Full record on ClinicalTrials.gov

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