Impact of Vertical vs. Transverse Closure on Outcomes of Laparoscopic Correction of Isthmocele
Starting soon · Not applicable
Conditions studied: Isthmocele
In brief
Laparoscopic repair of Isthmocele aims to restore the anatomical integrity and physiological function of the lower uterine segment. * Vertical Closure: This technique involves closing the defect along the longitudinal axis of the uterus. Proponents suggest it may be more anatomically aligned with the muscle fibers of the lower uterine segment, potentially leading to stronger scar formation and reduced tension. * Transverse Closure: This technique involves closing the defect perpendicular to the long axis of the uterus. This approach is more commonly used during primary cesarean sections. Arguments for transverse closure in isthmocele repair include familiarity for surgeons and potentially less shortening of the lower uterine segment. However, the actual impact of these different closure methods on long-term outcomes such as defect recurrence, scar integrity, and fertility, remains largely unexplored in a randomized controlled trial setting.
Key facts
- Study ID
- NCT07625852
- Run by
- Minia University
- People needed
- 72
- Starts
- 2026-06-01
- Expected to finish
- 2027-06-01
- Last updated by the study team
- 2026-06-04
Who can join
Age: 18 and older, up to 45. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- Women aged 18-45 years.
- Diagnosis of symptomatic isthmocele confirmed by transvaginal ultrasound (myometrial thickness at the defect < 2.5 mm).
- History of at least one prior cesarean section.
- Symptoms attributable to isthmocele (e.g., abnormal uterine bleeding, pelvic pain, dysmenorrhea, secondary infertility).
- Desire for surgical correction of isthmocele.
- Ability to understand and provide informed consent
You may not qualify if…
- Asymptomatic isthmocele.
- Active pelvic infection or malignancy.
- Significant medical comorbidities contraindicating laparoscopic surgery.
- Coagulopathy.
- Known uterine anomalies (e.g., bicornuate uterus).
- Pregnancy at the time of recruitment.
- Inability to comply with follow-up protocol.
Full record on ClinicalTrials.gov
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