Patient-Ventilator Asynchrony: Occurence and Clinical Impact in Usual Care

Starting soon

Conditions studied: Mechanical Ventilation, Patient-Ventilator Asynchrony

In brief

The goal of this observational study is to unravel the occurence, impact and relations of Patient-Ventilator Aynchrony (PVA) in mechanically ventilated patients. The main questions it aims to answer are: * How often does PVA occur? * What are relations between clinical characteristics and PVA occurence? * What are relations between PVA occurence and patient outcomes? All questions will be assessed using data collected during the whole course of mechanical ventilation. Mechanically ventilated patients' medical data will be re-used. PVAs will be automatically classified on ventilator waveform data, using validated Deep Breath software.

Key facts

Study ID

NCT07624786

Run by

Erasmus Medical Center

People needed

110

Starts

2026-06-01

Expected to finish

2027-02-01

Last updated by the study team

2026-06-03

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age > 18 years old.
• Recordings available of ventilator waveforms synchronized with the patient's electronic health record during invasive mechanical ventilation.
• Duration of mechanical ventilation of at least 24 hours.

You may not qualify if…

• (Previous) registered objection of patient and/or relatives to re-use clinical data for research purposes
• No consent for re-use of data for research

Where it is running

• Catharina Ziekenhuis Eindhoven (CZE) — Eindhoven, North Brabant, Netherlands
• Leiden University Medical Center (LUMC) — Leiden, South Holland, Netherlands
• Erasmus Medical Center (EMC) — Rotterdam, South Holland, Netherlands

Full record on ClinicalTrials.gov

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