Neural Mechanisms of Emotion-behaviour Interactions

Starting soon · Not applicable

Conditions studied: Healthy Volunteer

In brief

Deciding what to do when for how long - self-organizing one's behaviour - is an important feature of daily life. Emotions arise providing short-cuts for the computational complexities. Yet, one still knows relatively little about the underlying cognitive and neural mechanisms. EMOBB will establish the computational, cognitive and neural underpinnings of the rich interplay between emotions and self-organized behaviour in naturalistic environments. Previous work has almost exclusively relied on tasks structured into experimenter determined trials - thus how people self-organized behaviour could not be measured. To overcome this, EMOBB will combine novel naturalistic tasks in which people have freedom what to do when for how long with subjective and objective measurements of emotions. This will be made possible through a computational modelling approach that allows dissecting and quantifying even complex behaviour-emotion interactions. Specifically, EMOBB will use three cognitive tasks of emotion-behaviour interplay that participants will do while undergoing functional magnetic resonance brain imaging and monitoring of their facial expressions with an MRI-compatible camera. The primary hypothesis of EMOBB is that both unique and shared neural networks will underpin the interplay between emotions and behaviour across our cognitive tasks.

Key facts

Study ID

NCT07623746

Run by

Hospices Civils de Lyon

People needed

120

Starts

2026-10-01

Expected to finish

2030-10-10

Last updated by the study team

2026-06-03

Who can join

Age: 18 and older, up to 45. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 18-45 years old,
• fluent French speakers,
• healthy,
• without a beard at the time of testing,
• right-handed,
• being able to use both hands
• BMI between 18.5 and 30
• give written informed consen
• for women: contraception;

You may not qualify if…

• neurological, psychiatric disorders, or severe chronic disorders (diabetes, cardiac, kidney, lung, liver disorders, inflammatory disorders)
• pregnancy or breast-feeding
• under guardianship, currently admitted to a psychiatric hospital other than for research purposes)
• not wanting to be informed of abnormalities detected during MRI scan,
• taking part in other studies with exclusion periods,
• MRI exclusion criteria (cardiac pace maker etc, vascular or intracranial clamps or stents, neurological stimulator, any other metal in the body, past accidents with metal to the eyes, metallic prostheses, metal in the mouth (braces, retainers), medication pumps, any implants (e.g. hearing implants), piercings that cannot be removed, having worked with metal (other than radiography related to MRI) being claustrophobic, tatoos above the shoulders.

Where it is running

• CERMEP (Centre d'Etude de Recherche Multimodal et pluridisciplinaire en imagerie du vivant) — Bron, France

Full record on ClinicalTrials.gov

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