CAR-T Treatment in Pediatric and Adult Acute Lymphoblastic Leukemia

Starting soon

Conditions studied: Acute Lymphoblastic Leukemia, B-Cell Acute Lymphoblastic Leukaemia

In brief

The goal of this observational study is to evaluate the efficacy of the treatment with approved CAR-T cells in Italy in pediatric and adult patients with acute B-cell lymphoblastic leukemia. The main question it aims to answer is: which is the overall response rate in pediatric and adult patients with acute B-cell lymphoblastic leukemia treated with approved CAR-T cells? Data will be extracted from patients medical records.

Key facts

Study ID

NCT07623655

Run by

Gruppo Italiano Malattie EMatologiche dell'Adulto

People needed

107

Starts

2026-09-01

Expected to finish

2029-12-30

Last updated by the study team

2026-06-03

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of ALL R/R CD19+
• Patients are pediatric (all patients up to the age of 18) adult (all comers older than 18)
• Prescribed treatment with Tisagenlecleucel or Brexucabtagene autoleucel as per approved AIFA criteria, or obecabtagene autoleucel - as well as other products - when available
• Provided consent (or did not opposed) for collection and use of patient data per local regulations

You may not qualify if…

• None

Full record on ClinicalTrials.gov

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