Titration of Positive End-expiratory Pressure: Comparison Between Manual Thoracic or Abdominal Compression and Electrical Impedance Tomography

Recruiting now · Not applicable

Conditions studied: ARDS (Acute Respiratory Distress Syndrome)

In brief

Patients with acute respiratory distress syndrome are placed on mechanical ventilation, and the adjustment of ventilator parameters is an important step in their care, in particular positive expiratory pressure, applied at the end of breathing. The goal of this study is to learn if continuous anterior chest compression works as well as electrical impedance tomography for positive expiratory pressure titration. Researchers will compare the two methods for each patient, in a randomly determined order : continuous anterior chest compression and electrical impedance tomography. Participants will : * have a pep titration with both techniques * be included in the study for 28 days

Key facts

Study ID

NCT07623590

Run by

Centre Hospitalier Saint Joseph Saint Luc de Lyon

People needed

30

Starts

2025-04-07

Expected to finish

2027-05-05

Last updated by the study team

2026-06-03

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 18 years
• Moderate to severe ARDS according to the Berlin criteria
• Patient receiving sedation and continuous curarization
• Free and informed consent from the patient or their loved one

You may not qualify if…

• ECMO
• Pneumothorax
• Chest trauma in the last 3 months
• Uncontrolled shock (noradrenaline > 5 mg/h)
• Pregnant or breastfeeding woman
• Protected adult within the meaning of the law
• Lack of social security
• Patient under AME

Where it is running

• GHU Henri Mondor — Créteil, France (enrolling)
• Hôpital Saint Joseph Saint Luc — Lyon, France (enrolling)

Full record on ClinicalTrials.gov

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