AI-Guided Intensified Follow-up After Surgery for Acute Type A Aortic Dissection

Starting soon · Not applicable

Conditions studied: Acute Type A Aortic Dissection, Stanford Type A Aortic Dissection, Postoperative Aortic Dissection Follow-up

In brief

This multicenter, prospective, randomized controlled trial will evaluate whether an artificial intelligence (AI) multimodal prediction model-guided intensified follow-up strategy improves 1-year outcomes after surgery for acute Stanford type A aortic dissection. Eligible adult patients who have undergone open surgical repair or open plus endovascular/hybrid repair and are clinically stable to enter the postoperative follow-up phase will be randomized 1:1 to usual postoperative follow-up or AI-guided intensified follow-up. The AI-guided arm will receive usual follow-up plus an AI-generated risk stratification report for 1-year mortality and adverse aortic remodeling. Higher-risk patients may receive more frequent follow-up, prioritized CTA review, multidisciplinary assessment, and targeted management reminders. The primary outcome is all-cause mortality through postoperative day 365. Key secondary outcomes include aortic reintervention, adverse aortic remodeling, and ICU readmission within 1 year.

Key facts

Study ID

NCT07623213

Run by

Second Affiliated Hospital, Zhejiang University, School of Medicine

People needed

1314

Starts

2026-12-01

Expected to finish

2029-12-01

Last updated by the study team

2026-06-03

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 1. Age 18 years or older. 2. Acute Stanford type A aortic dissection confirmed by CTA, intraoperative findings, or medical records.
• Underwent open surgical repair or open repair combined with endovascular/hybrid repair.
• Postoperative condition is stable and the patient is planned for discharge or has entered early post-discharge follow-up.
• Core baseline data required for AI model operation are available, including at least one eligible preoperative or postoperative CTA imaging dataset.
• Able to complete telephone, outpatient, or inpatient follow-up and willing to provide written informed consent.

You may not qualify if…

• 1. Predominantly chronic type A dissection, traumatic dissection, or iatrogenic dissection, if the investigator judges the patient unsuitable for this follow-up strategy study.
• Did not undergo surgical repair, received only palliative treatment, or did not meet postoperative randomization conditions.
• Expected inability to complete 12-month follow-up, no stable contact information, or inability to obtain outpatient, telephone, or inpatient follow-up data.
• Severe missing baseline data preventing generation of the AI risk report. 5. Concurrent participation in another interventional study that may substantially affect postoperative follow-up intensity or the primary outcome.
• Any other condition that, in the investigator's judgment, makes the patient unsuitable for participation.

Full record on ClinicalTrials.gov

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