Variable Intense Training for Ataxia and Locomotion

Starting soon · Not applicable

Conditions studied: Cerebellar Disorders, Cerebellar Degeneration, Cerebellar Atrophy, Cerebellar Lesions

In brief

The goal of this study is to evaluate the feasibility and potential preliminary efficiency of high-intensity training focused on stepping in variable contexts as compared to conventional training in individuals with cerebellar disease

Key facts

Study ID

NCT07621978

Run by

Indiana University

People needed

20

Starts

2026-06-15

Expected to finish

2028-12-15

Last updated by the study team

2026-06-02

Who can join

Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Ages 18-85
• >6 months following brain injury or diagnosis of cerebellar dysfunction
• A total score of > 4 on items 5-8 on the SARA for the ipsilateral limb
• Ability to ambulate 10 m at self-selected gait speeds (SSV) <1.2 m/s with no greater than minimal physical assistance permitted for postural stability only, but with below knee bracing and/or assistive device as needed
• Weight < 350 pounds
• Able to follow 1-step command
• Medical clearance to participate

You may not qualify if…

• Uncontrolled cardiopulmonary or metabolic disease that limits exercise participation, active heterotopic ossification, recurrent history of lower extremity fractures, previous orthopedic or other peripheral or central neurologic injury that may impair locomotor activities
• Currently participating in other physical therapy
• >50 units of Botox within the past three months in the lower extremity OR in the lower extremity, but above the knee if the participant wears an ankle-foot-orthosis
• Individuals deemed not stable between Pre-Baseline Testing and Baseline Testing

Full record on ClinicalTrials.gov

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