The Implementation of Genetic Risk for Colorectal Cancer Screening

Enrolling by invitation

Conditions studied: Colorectal Cancer, Colorectal Adenoma, Colorectal Polyp

In brief

The goal of this study is to investigate genetic risk for colorectal cancer utilizing polygenic risk scores (PRS) for adults over 45 who have not received their first colonoscopy. The main questions it hopes to address are: 1. How does knowledge of a patient's genetic risk for colorectal cancer affect the uptake of initial screening colonoscopies? 2. How do colonoscopy outcomes compare between genetic risk groups?

Key facts

Study ID

NCT07621757

Run by

Endeavor Health

People needed

100

Starts

2026-06-01

Expected to finish

2027-05-31

Last updated by the study team

2026-06-02

Who can join

Age: 45 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Due for initial screening colonoscopy per current guidelines

You may not qualify if…

• Prior colonoscopy
• Prior personal history of colorectal cancer or inflammatory bowel disease
• Medical contraindications to colonoscopy/sedation

Where it is running

• Endeavor Health — Evanston, Illinois, United States

Full record on ClinicalTrials.gov

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